Project 1: Small Molecule Entry Inhibitors of Pandemic Viruses

Project 1: Small Molecule Entry Inhibitors of Pandemic Viruses, Virus entry steps. (1) Receptor ACE2 recognition by the spike protein. (2) Refolding of the S2 subunit in the spike protein after the ACE bound S1 subunit is dissociated. (3) Lipid mixing between the host membrane and the viral membrane. This step completes the virus entry, releasing the viral RNA genome into the host cytoplasm to initiate replication. (Koppisetti et al. J. Am. Chem. Soc. 2021, 143, 33, 13205–13211),

Virus entry steps. (1) Receptor ACE2 recognition by the spike protein. (2) Refolding of the S2 subunit in the spike protein after the ACE bound S1 subunit is dissociated. (3) Lipid mixing between the host membrane and the viral membrane. This step completes the virus entry, releasing the viral RNA genome into the host cytoplasm to initiate replication. (Koppisetti et al. J. Am. Chem. Soc. 2021, 143, 33, 13205–13211)

Project 1: Small Molecule Entry Inhibitors of Pandemic Viruses, Virus entry steps. (1) Receptor ACE2 recognition by the spike protein. (2) Refolding of the S2 subunit in the spike protein after the ACE bound S1 subunit is dissociated. (3) Lipid mixing between the host membrane and the viral membrane. This step completes the virus entry, releasing the viral RNA genome into the host cytoplasm to initiate replication. (Koppisetti et al. J. Am. Chem. Soc. 2021, 143, 33, 13205–13211)

Principal Investigator

ming luo, georgia state university, Project 1: Small Molecule Entry Inhibitors of Pandemic Viruses

Ming Luo, Ph.D

 [email protected]

Georgia State University, UT San Antonio Health, University of Iowa, Iowa State University, Nanyang technical university, University of Illinois Chicago, University of Louisville, University of Tennessee, university of Minnesota, UC Berkeley, UC San Diego, UF Scripps Biomedical Research, Baylor, Boston University, New York Blood Center,

Deputy Investigator

Michael Farzan, UF Scripps Biomedical Research, Lab Leak, Covid-19, Project 1: Small Molecule Entry Inhibitors of Pandemic Viruses

Michael Farzan, Ph.D

[email protected]

harvard

Deputy Investigator

Choe Hyeryun, Project 1: Small Molecule Entry Inhibitors of Pandemic Viruses, UF Scripps Biomedical Research

Hyeryun Choe, Ph.D

[email protected]

harvard

Co-Investigators and Other Significant Contributors (OSC)

Fang Li, Ph.D: University of Minnesota, coronavirus research center, spike protein, Midwest AViDD, University of minnesota, llama, lab leak, wuhan,

Fang Li, Ph.D: University of Minnesota

[email protected]

Asim Debnath, Ph.D: New York Blood Center, OSC

Asim Debnath, Ph.D: New York Blood Center, OSC

 [email protected]

Lijun Rong, Ph.D: University of Illinois Chicago

Lijun Rong, Ph.D: University of Illinois Chicago

[email protected]

Lanying Du, Ph.D: Georgia State University, lab leak, covid-19, wuhan

Lanying Du, Ph.D: Georgia State University

[email protected]

Irina Gaisana, Ph.D: University of Illinois Chicago

Irina Gaisana, Ph.D: University of Illinois Chicago

[email protected]

Binghe Wang, Ph.D: Georgia State University

Binghe Wang, Ph.D: Georgia State University

 [email protected]

Mukesh Kumar, Ph.D: Georgia State University

Mukesh Kumar, Ph.D: Georgia State University

[email protected]

Norton Peet, Drug Development, University of Nebraska, United States Chemist Society, AstraZeneca

Norton Peet, Ph.D: Consultant, OSC