The Core E's cellular and organismic systems support the entire Center by coordinating and implementing cell and animal antiviral testing experiments.
Because of the intense requirements for handling pathogens that require high containment, Core E provides consistency in determining the antiviral activity of each compound.
Based at the University of Minnesota, Boston University, and the University of Iowa, the cellular and organismic systems Core provides the specialized resources and administrative framework for performing cellular and animal studies.
Core E will focus on SARS-CoV-2, Zika, Ebola, and Lassa. This core will evaluate validated hits through high throughput screening. Successful compounds will then return to the projects and cores for further refinement.
We will then evaluate refined compounds for antiviral activity, dose-response, the potential for escape, and efficacy in primary human cells.
Finally, compounds demonstrating prophylactic and therapeutic efficacy will be evaluated in relevant animal disease models.